FOX | 8:00 pm
"Family Guy" mentor Seth MacFarlane applies his sensibilities — not all of them comedic — to the premiere of this outer-space saga. The intergalactic vessel Orville’s part-human, part-alien crew gets lots of life lessons while crossing the cosmos. Series creator and executive producer MacFarlane plays the ship’s commander, sharing duties with a first officer (Adrianne Palicki, "Marvel’s Agents of S.H.I.E.L.D.") who’s his ex-wife. Scott Grimes also stars.