The Big Bang Theory

CBS | 8:00 pm

The Emmy-winning comedy blockbuster opens its 12th and final season with "The Conjugal Configuration," which finds Sheldon and Amy (Jim Parsons, Mayim Bialik) running into some problems with their honeymoon in New York. Meanwhile, back in California, Penny and Leonard (Kaley Cuoco, Johnny Galecki) are a little freaked out to discover how much they have in common with Amy’s parents, and Koothrappali (Kunal Nayyar) ignites a Twitter war with physicist Neil deGrasse Tyson (guest starring as himself).