A&E | 10:00 pm

This still-powerful Emmy-winning docuseries, which looks at addicts who are running out of options and the impact of their disease on those around them, returns for Season 21 with a premiere that focuses on Melanie, who was only 8 when her father committed suicide. Raised by a fragile single mom, Melanie started acting out to get attention during her adolescence and discovered crack cocaine by age 14. Years later, Melanie is a single mother herself with a crack habit that threatens her custody of the son she adores.