CW | 8:00 pm

Richard Speight Jr., who has played multiple guest roles on this action thriller during its long broadcast history, directs tonight's new episode "Despair," which finds Sam and Dean (Jared Padalecki, Jensen Ackles) teaming up with Castiel and Jack (Misha Collins, Alexander Calvert) in service to the common good, now that their plan against Chuck has swung into motion.