Station 19

ABC | 8:00 pm

The "Grey's Anatomy" spinoff opens Season 4 with "Nothing Seems the Same," a title that, in part, refers to how these gallant first responders are trying to adjust to the challenging new reality of the COVID-19 pandemic, which complicates their efforts to render critical assistance to victims in a timely manner. Elsewhere, Andy (Jaina Lee Ortiz) is still reeling to learn her mother, long presumed dead, is alive. The episode also kicks off a heavily promoted three-hour crossover event with "Grey's Anatomy," which immediately follows.