Stand Up to Cancer

E! | 8:00 pm

Executive produced by Oscar winning actress Reese Witherspoon and her husband, Jim Toth, this year's hour-long fundraising event originates live from Los Angeles and airs simultaneously on more than 60 media platforms across the U.S. and Canada. The coverage includes all four major U.S. networks — ABC, CBS, Fox and NBC — which are donating an hour of commercial-free airtime. Ken Jeong and his wife, physician Tran Ho, a cancer survivor herself, are co-hosts, along with Anthony Anderson and Sofía Vergara, with Common and Brittany Howard among the performers.